If your dog has recently started panting more than usual while taking prednisone, you’re not alone. Panting is one of the most common side effects of this steroid medication—and while it can seem alarming, it’s not always a cause for concern.
We outline why dogs pant on prednisone, how to manage the side effects at home, and when it’s time to talk to your vet.
Why Is My Dog Panting on Prednisone — What It Means
Panting while on prednisone is a well-known and expected side effect, often due to the medication’s effects on metabolism, fluid balance, and stress hormones. Your dog’s body is adjusting to synthetic corticosteroids, which can stimulate appetite, thirst, and temperature regulation.

Common Reasons Dogs Pant on Prednisone
1. Increased Metabolism
Prednisone speeds up your dog’s metabolism, which can raise their internal temperature. To cool down, they’ll pant more frequently—even while at rest.
2. Hormonal Effects
Corticosteroids mimic cortisol, the stress hormone. This can lead to a stress-like physiological response, including restlessness and panting.
Even if your dog seems calm, their body may be feeling the opposite due to the hormonal shift.
3. Increased Thirst and Urination
Prednisone causes excessive drinking and urination in most dogs. As your dog drinks more, they may also experience mild bloating or increased body heat, leading to panting.
4. Anxiety or Discomfort
Some dogs become more anxious or agitated on prednisone. Panting in this case is tied to emotional stress or discomfort, especially if the dose is high or the treatment has just begun.
Read more: Dog Panting and Shaking (Fear or something deeper?)
5. Fluid Retention or High Blood Pressure
In rare cases, prednisone can lead to fluid retention or elevated blood pressure. These conditions can make your dog feel overheated or uncomfortable, which may also result in panting.
How Long Will My Dog Pant on Prednisone?
In many cases, dogs start panting within a few days of starting prednisone, especially at moderate to high doses. The panting may continue throughout the treatment period, and usually subsides when the dose is lowered or the medication is stopped.
Your vet may recommend tapering the dose gradually, which can help reduce panting and other side effects.
What You Can Do at Home
Keep your dog cool. Provide plenty of water and a fan or cooling mat if needed.
Maintain a quiet, low-stress environment. Stress can worsen panting and anxiety.
Stick to the dosing schedule. Don’t adjust the dose without veterinary advice.
Track the symptoms. Monitor when and how often your dog pants, and note any other changes.
When to Call Your Vet
Contact your veterinarian if your dog:
Is panting excessively and won’t settle down
Is lethargic or vomiting
Refuses to eat or drink
Has labored breathing or wheezing
Seems more anxious or agitated than usual
Your vet may decide to adjust the dose or switch to an alternative treatment depending on the severity of the side effects.
Read more: Dog Panting Excessively and Shaking (What it means)
Key Takeaway
Panting is a common reaction to prednisone in dogs and is usually manageable. Still, any sudden or severe changes in your dog’s behavior should be checked by a vet.
By staying informed and observant, you can help your dog stay comfortable while getting the treatment they need.